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Dietary long‐chain polyunsaturated fatty acids modify heart, kidney, and lung fatty acid composition in weanling rats
Author(s) -
Suárez A.,
Faus M. J.,
Gil A.
Publication year - 1996
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02529883
Subject(s) - weanling , polyunsaturated fatty acid , fish oil , weaning , fatty acid , food science , phospholipid , biology , composition (language) , lipidology , arachidonic acid , kidney , chemistry , medicine , biochemistry , endocrinology , fish <actinopterygii> , linguistics , philosophy , membrane , fishery , enzyme
The fatty acid composition of heart, kidney, and lung was studied in weanling rats fed three diets differing in their polyunsaturated fatty acid content for 0, 2, and 4 wk. The first group had a 10% w/w fat semipurified diet which consisted of a mixture of olive oil (62.5%), soybean oil (11.1%), and refined coconut oil (26.4%) and provided 18:1n‐9, 18:2n‐6, and 18:3n‐3 in similar amounts to a maternal human milk (diet HO). The second group received 7% of HO fat and 3% fish oil (0.4% 20:4n‐6 and 5% 22:6n‐3 of total fatty acids) (diet FO), and the third group was fed 7% HO fat, 1.5% of the same fish oil, and 1.5% of a purified pig brain phospholipid concentrate (0.6% 20:4n‐6 and 3.5% 22:6n‐3 of total fatty acids) (diet FO+BPL). The experimental diets increased tissue monounsaturated fatty acids in comparison with rats at weaning. Tissue lipid content of 20:4n‐6 was increased and 22:6n‐3 decreased in Group HO compared with weanling rats, whereas opposite changes were observed in Group FO. Feeding diet FO+BPL increased 22:6n:3 in tissue lipids compared with diet HO, and increased 20:4n‐6 content in relation to diet FO. Our results indicate that rat heart, kidney, and lung are highly responsive to dietary n‐3 and n‐6 long‐chain polyunsaturated fatty acids during postnatal life.