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Application of immobilized lipase in production of camptosar (CPT‐11)
Author(s) -
Sih John C.
Publication year - 1996
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02523499
Subject(s) - lipase , acylation , catalysis , chemistry , solvent , pseudomonas , organic chemistry , alcohol , organic solvent , chromatography , enzyme , chemical engineering , bacteria , biology , engineering , genetics
Lipase from Pseudomonas cepaica (Amano, PS‐30) was immobilized on celite and used in organic solvent for the selective acylation of a key alcohol intermediate. The compound was transformed in the synthesis to the anticancer drug Camptosar (CPT‐11). Catalyst activity was influenced by the water content and method used to dry the catalyst. This resolution has been conducted on production scale with equal weight of recyclable catalyst.