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Biocatalytic synthesis of some chiral pharmaceutical intermediates by lipases
Author(s) -
Patel Ramesh N.,
Banerjee Amit,
Szarka Laszlo J.
Publication year - 1996
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02523498
Subject(s) - biocatalysis , chemistry , lipase , organic chemistry , catalysis , combinatorial chemistry , enzyme , reaction mechanism
Chiral intermediates were prepared by biocatalytic processes for the chemical synthesis of three pharmaceutical drug candidates. These include (i) the synthesis of [(3 R‐cis )‐3‐(acetyloxy)‐4‐phenyl‐2‐azetidinone 2 for the semi‐synthesis of paclitaxel (taxol) 5 , an anticancer compound; (ii) synthesis of chiral (exo,exo)‐7‐oxabicyclo [2.2.1] heptane‐2,3‐dimenthanol monoacetate ester 9 for the chemoenzymatic preparation of a thromboxane A 2 antagonist; (iii) the enzymatic synthesis of S ‐(−) 3‐benzylthio‐2‐methylpropanoic acid, a key chiral intermediate for the synthesis of antihypertensive drugs captopril 10 or zofenopril 13 .