Premium
Clinicopathologic evaluation of mucin‐producing tumor of the pancreas
Author(s) -
Takahashi Toshiyuki,
Dohke Mitsuru,
Okushiba ShunIch,
Okushiba Tomoo,
Katoh Hiroyuki
Publication year - 1997
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/bf02489782
Subject(s) - medicine , pancreas , endoscopic ultrasound , endoscopic ultrasonography , duodenum , endoscopy , radiology , mucin , pathology , general surgery , gastroenterology
We studied the diagnostic problems, surgical management, and histopathologic characteristics of 28 patients with intra‐ductal tumors and mucinous cystadenomas of the pancreas who underwent surgical resection. Endoscopic ultrasonography (EUS) and endoscopic retrograde pancreatography (ERP) were the most useful means for confident diagnosis of the diseases. New diagnostic modalities, including intra‐pancreatic ductal endoscopy and intraductal ultrasonography, also improved the qualitative diagnosis of these tumors. Minimally invasive surgery i.e., duodenum‐and choledochus‐preserving resection of the head of the pancreas, was conducted in our patients. The long‐term results were good and no patients had disease recurrence. Although these diseases are regarded as precancerous lesions of the pancreas, there were several unclear points regarding biologic behavior and the correlation with invasive cystadenocarcinoma. Thus, a molecular biological explanation concerning the roles of oncogenes such as p53 and Ki‐ ras in carcinogenesis is an important question that remains to be resolved.