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Assessment of hepatic function by blood ketone body ratio
Author(s) -
Tanaka Akira,
Yamaoka Yoshio
Publication year - 1997
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/bf02489020
Subject(s) - ketone bodies , ketone , nad+ kinase , mitochondrion , hepatic function , medicine , redox , chemistry , arterial blood , biochemistry , endocrinology , metabolism , enzyme , organic chemistry
The arterial blood ketone body ratio is a non‐invasive means of evaluating mitochondrial ATP synthesis and the related energy status of the liver, in which arterial blood is used, instead of the sampling of liver tissue or the isolation of mitochondria. We discuss AKBR in relation to: ATP synthesis, the rationale of using AKBR for assessment of the intramitochondrial redox state, factors affecting the intramitochondrial redox state, regulation of the speed of ATP synthesis by the oxidized/reduced form of pyridine nucleotid (NAD + /NADH) ratio, and the clinical applications of AKBR.