Premium
Comparison of Euro‐Collins and University of Wisconsin solutions in adult human cadaveric liver transplantation
Author(s) -
Abe Tsuyoshi,
Lynch Stephen V.,
Balderson Glenda A.,
Pillay Pragalathan S.,
Wall Daryl R.,
Akiyama Takashi,
Shimizu Yasunobu,
Matsunami Hidetoshi,
Strong Russell W.
Publication year - 1994
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/bf02391081
Subject(s) - viaspan , alkaline phosphatase , liver transplantation , transplantation , medicine , bilirubin , prothrombin time , perioperative , reperfusion injury , surgery , andrology , urology , gastroenterology , chemistry , biochemistry , ischemia , enzyme
To characterize the potential utility of the University of Wisconsin (UW) solution, 37 grafts preserved in UW solution (UW group) were compared with 38 grafts preserved in Euro‐Collins (EC) solution (EC group). Patients in both groups underwent similar perioperative management. Donor and recipient data in the two groups were similar. The mean cold ischemia time (CIT) of the UW group was 6.51±2.06 h (range: 3.17–14.65 h); this was significantly longer than that of the EC group, of 4.80±1.68 h (range: 1.67–8.83h) ( P <0.05). There were no significant differences in actuarial patient or graft survival between the two groups. Blood concentrations of aspartate aminotransferase (AST) within 12 h and lactic dehydogenase (LDH) within 6 h of reperfusion were significantly lower in the UW group than in the EC group, each being ( P <0.05). The total bilirubin (TBR) concentration was lower in the UW group than in the EC group, but the difference was not significant. Alkaline phosphatase (ALP), gamma glutamyl transpeptidase (GGTP), and prothrombin time (PT) showed no significant differences between the two groups. There was no difference in the frequency of complications or rejection episodes between the two groups. However, gender identical grafts had a lower rejection than gender non‐identical grafts in the UW group ( P <0.05). Our data suggest that the UW solution reduces transplantation‐related graft injury compared with the EC solution.