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Administration of branched chain amino acids prevents bacterial translocation after liver resection in the cirrhotic rat
Author(s) -
Higashiguchi Takashi,
Ito Akihiro,
Kitagawa Masato,
Taoka Hiroki,
Kawarada Yoshifumi
Publication year - 1996
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/bf02391030
Subject(s) - enteral administration , cirrhosis , bacterial translocation , thioacetamide , chromosomal translocation , sepsis , protein biosynthesis , metabolism , parenteral nutrition , amino acid , biology , gastroenterology , medicine , biochemistry , gene
After major liver resection, bacterial infectious complications, including sepsis and endotoxemia, can be at least in part, attributed to translocation of enteric bacteria and endotoxin. We evaluated the effectiveness of the enteral and parenteral administration of branched‐chain amino acids (BCAA) in preventing bacterial translocation after 70% liver resection in rats with thioacetamide‐induced‐cirrhosis. Bacterial translocation after hepatectomy was induced by a disturbance of protein metabolism in intestinal epithelial cells. However, the administration of BCAA, particularly via the enteral route, improved amino acid metabolism in the gut and stimulated the synthesis of nonsecreted protein and the proliferation of crypt cells, thereby preventing bacterial translocation after liver resection. Improvement in this cascade of metabolic reactions is believed to have been responsible for the improved outcome after extensive resection of the cirrhotic liver.