Premium
Gene expression in synchronous tumors in different organs: Pancreas and other organs
Author(s) -
Satake Katsusuke
Publication year - 1996
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/bf02350928
Subject(s) - exon , pancreatic cancer , pancreas , gene , cystadenoma , mutation , colorectal cancer , cancer research , biology , gene mutation , cancer , medicine , genetics
The genetic changes linked to the development of synchronous double tumors were investigated in two patients, by analyzing mutations in codon 12 of the k‐ ras gene and exons 5–8 of the p53 gene. One patient had pancreatic and renal cancers. The pancreatic cancer had a mutation in codon 12 of the k‐ ras gene. The second patient had pancreatic cystadenoma and rectal cancer. The rectal cancer had a mutation in exon 8 ofthe p53 gene. The associated pancreatic cystadenoma and renal cancer in these patients did not show any mutations of these genes. The genetic changes leading to the development of the synchronous double tumors were different in each of the tumors, suggestive of the involvement of other genetic changes, despite the tumors having developed under the same environmental conditions.