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Clinical analysis of TS1 carcinoma of the pancreas
Author(s) -
Hatori Takashi,
Imaizumi Toshihide,
Nakasako Toshiaki,
Harada Nobuhiko,
Hanyu Fujio,
Takasaki Takeshi
Publication year - 1995
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/bf02349250
Subject(s) - medicine , pancreatic cancer , survival rate , metastasis , stage (stratigraphy) , endoscopic ultrasonography , lymph node metastasis , pancreas , gastroenterology , group b , cancer , radiology , oncology , endoscopy , paleontology , biology
In 40 patients with tumor size (TS)1 pancreatic cancer with a TS of 2 cm or less, the tumor was classified as without direct extrapancreatic invasion in 11 patients (t 1 a, group) and as with direct extrapancreatic invasion in 29 patients (t 2 t 3 group). Ultrasonography (US) and endoscopic retrograde cholangio‐pancreatography (ERCP) were useful for the diagnosis, with accuracy rates of 80% and 75%, respectively, in the t 1 a group and and% 78 75% in the t 2 t 3 group. The accuracy rate of preoperative integrated imaging diagnosis was 83% in the t 2 t 3 group but only 55% in the t 1 a group. All of the t 2 t 3 patients were stage III or higher and 18% of the t 1 a patients had lymph node metastasis, indicating the need for extended radical operation in TS1 pancreatic cancer. Because standard operation is indicated when the preoperative diagnosis is not pancreatic cancer, accurate preoperative diagnosis is very important. The rate of curative resection and the 5‐year survival rate were 100% and 56%, respectively, in the t 1 a group and there were two 5‐year survivors. The rate of non‐curative resection and the 5‐year survival rate were 31% and 35%, respectively, in the t 2 t 3 group and there were three 5‐year survivors. In the light of these findings, it is therefore important to make an accurate diagnosis of t 1 a pancreatic cancer of TS1 pancreatic cancer without direct extrapancreatic invasion. As liver metastasis was frequently observed in both the t 1 a and t 2 t 3 groups, the establishment of effective measures to inhibit liver metastasis is considered urgent to improve the result of TS1 pancreatic cancer surgery.