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Uptake of lysosomal enzymes by human fibroblasts: Lack of uptake of fungal or plant glycosidases in comparison with a mammalian enzyme
Author(s) -
Dooley K. C.,
Applegarth D. A.
Publication year - 1980
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf02312548
Subject(s) - enzyme , fabry disease , alpha galactosidase , human placenta , biochemistry , fibroblast , placenta , biology , enzyme replacement therapy , microbiology and biotechnology , disease , medicine , fetus , in vitro , genetics , pregnancy
α‐Galactosidase from human placenta was actively taken up by cultured fibroblasts from patients with Fabry's disease whereas the enzyme from the fig was not absorbed. α‐Glucosidase from two microbiological sources, A. fumigatus and A. niger , was not taken up by cultured fibroblasts from patients with Pompe's disease.