The 4‐methylumbelliferone sulphate sulphatases of human tears | Zendy

Jordan T. W. | Zendy; Heiss F. | Zendy; Monk B. | Zendy; Nicholls J. | Zendy

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The 4‐methylumbelliferone sulphate sulphatases of human tears

Author(s) -

Jordan T. W.,

Heiss F.,

Monk B.,

Nicholls J.

Publication year - 1980

Publication title -

journal of inherited metabolic disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.462

H-Index - 102

eISSN - 1573-2665

pISSN - 0141-8955

DOI - 10.1007/bf02312523

Subject(s) - tears , metachromatic leukodystrophy , isoelectric focusing , enzyme , chemistry , isoelectric point , biochemistry , enzyme assay , population , normal population , biology , medicine , immunology , environmental health

The properties of human tear 4‐methylumbelliferone sulphate sulphatase (EC 3.1.6.1) have been investigated. More than 80% of the enzyme activity behaved as the acidic A isoenzyme on isoelectric focusing and DEAE‐cellulose ion exchange chromatography. The distribution of enzyme activity in a normal population has been investigated. The least interindividual variation was seen when enzyme activities were calculated as units per mg tears. The α‐galactosidase. Β‐ N ‐acetylglucosaminidase and sulphatase enzyme activities in human tears varied independently of each other. The use of tear sulphatases for the detection of metachromatic leukodystrophy (McKusick 24980) is discussed.

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