Premium
Evidence for an hereditary defect in taurine transport in the ciliary epithelium of an inbred strain of rabbits
Author(s) -
Harris T. M.,
Nance C. S.,
Sheppard L. B.,
Fox R. R.
Publication year - 1983
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf02310874
Subject(s) - taurine , endocrinology , medicine , allele , strain (injury) , biology , inbred strain , genotype , gene , genetics , amino acid
The concentration of taurine in the aqueous humour and serum of 21 rabbits with hereditary buphthalmia (Bu rabbits‐genotype bu/bu ) was compared with the aqueous and serum taurine levels of eight strain‐related normal rabits (JAX) and nine non‐strain‐related normal rabbits (MCV). There was a significant difference in the mean aqueous taurine concentration in each of the three groups. The Bu rabbits had only 29% of the MCV rabbits' level while the JAX rabbits were intermediate with 56% of the MCV level. It is suggested that some of the JAX rabbits may be heterozygous and the Bu rabbits homozygous for a semi‐dominant allele of a gene that is less efficient in taurine transport in the ciliary epithelium than the normal allele represented by the MCV animals.