Increased sensitivity of cerebrohepatorenal syndrome fibroblasts to antimycin A | Zendy

Kelley R. I. | Zendy; Corkey B. E. | Zendy

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Increased sensitivity of cerebrohepatorenal syndrome fibroblasts to antimycin A

Author(s) -

Kelley R. I.,

Corkey B. E.

Publication year - 1983

Publication title -

journal of inherited metabolic disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.462

H-Index - 102

eISSN - 1573-2665

pISSN - 0141-8955

DOI - 10.1007/bf02310872

Subject(s) - antimycin a , rotenone , mitochondrion , fibroblast , coenzyme q – cytochrome c reductase , cytochrome , electron transport chain , chemistry , microbiology and biotechnology , biology , cytochrome c , biochemistry , genetics , enzyme , cell culture

The effect of four mitochondrial electron transport inhibitors on the growth of normal and cerebrohepatorenal syndrome (CHRS) fibroblasts was studied. Compared to normal fibroblasts, CHRS cells demonstrated a fivefold greater sensitivity to antimycin A, an inhibitor of the cytochrome bc 1 complex (complex III), but equal inhibition by amytal, rotenone and 2‐heptyl‐4‐hydroxyquinoline‐ N ‐oxide. The results suggest a primary or secondary functional deficiency at mitochondrial complex III in fibroblasts.

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