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Corrective factor of bloom syndrome: Further characteristics
Author(s) -
Bartram C. R.,
Rüdiger H. W.
Publication year - 1981
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf02263628
Subject(s) - bloom syndrome , xeroderma pigmentosum , chromosome instability , genetics , bloom , biology , sister chromatids , sister chromatid exchange , chromosome , in vitro , dna , dna repair , gene , helicase , ecology , rna
Bloom syndrome is an autosomal recessive inherited disease characterized in vitro by chromosomal instability and an increased rate of sister chromatid exchanges (SCE). Co‐cultivation of Bloom syndrome and normal fibroblasts results in correction of chromosomal instability in Bloom syndrome. We report our studies of the effects of co‐cultivation on homozygous Bloom cells with heterozygous cells. Additionally, we used fibroblasts from a patient with Fanconi anaemia and with xeroderma pigmentosum.