Estimation of energy metabolism in human skeletal muscle homogenate as a diagnostic aid | Zendy

Ruitenbeek W. | Zendy; Sengers R. C. A. | Zendy; Trijbels J. M. F. | Zendy; Stadhouders A. M. | Zendy; Janssen A. J. M. | Zendy

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Estimation of energy metabolism in human skeletal muscle homogenate as a diagnostic aid

Author(s) -

Ruitenbeek W.,

Sengers R. C. A.,

Trijbels J. M. F.,

Stadhouders A. M.,

Janssen A. J. M.

Publication year - 1981

Publication title -

journal of inherited metabolic disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.462

H-Index - 102

eISSN - 1573-2665

pISSN - 0141-8955

DOI - 10.1007/bf02263606

Subject(s) - skeletal muscle , creatine , metabolite , human muscle , enzyme , energy metabolism , metabolism , biochemistry , medicine , incubation , endocrinology , biology , chemistry

A method is presented for the in vitro testing of the energy metabolism of human skeletal muscle. The levels of creatine phosphate, ATP, ADP and AMP, which are defined by the activity of many enzyme systems, are measured after incubation of the muscle homogenate with various substrates in the presence or absence of specific inhibitors. Detection of abnormal metabolite concentrations is important for diagnosis of patients with myopathic syndromes.

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