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Use of α‐methylphenylalanine for studies of brain development in experimental phenylketonuria
Author(s) -
Huether G.,
Neuhoff V.
Publication year - 1981
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf02263594
Subject(s) - hyperphenylalaninemia , phenylalanine , cerebellum , brain development , phenylketonurias , medicine , endocrinology , neuroscience , psychology , biology , biochemistry , amino acid
Experimental phenylketonuria was induced in newborn rats by administration of l ‐phenylalanine and α‐methylphenylalanine. There was no primary disturbance of myelination, but reduced cell proliferation, early cell death and compensatory hyperplasia were evident in the cerebellum.