CD4 deficiency in myelodysplastic syndrome with monosomy 7 | Zendy

C. M. R. Weemaes | Zendy; F. Preijers | Zendy; G. A. M. de Vaan | Zendy; J. A. J. M. Bakkeren | Zendy; Ina S. Klasen | Zendy; Ásgeir Haraldsson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

CD4 deficiency in myelodysplastic syndrome with monosomy 7

Author(s) -

C. M. R. Weemaes,

F. Preijers,

G. A. M. de Vaan,

J. A. J. M. Bakkeren,

Ina S. Klasen,

Ásgeir Haraldsson

Publication year - 1996

Publication title -

european journal of pediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.984

H-Index - 93

eISSN - 1432-1076

pISSN - 0340-6199

DOI - 10.1007/bf02075758

Subject(s) - medicine , monosomy , myelodysplastic syndromes , bone marrow , pediatrics , aneuploidy , immunology , pathology , karyotype , genetics , chromosome , gene , biology

We describe a patient with myelodysplastic syndrome with monosomy 7 presenting with a T-cell defect. He suffered from infections from the age of 10 years, when a CD4 deficiency and impaired lymphoproliferative responses in vitro were found. The only symptom of a myelodysplastic syndrome at that time was thrombocytopenia with giant platelets. Monosomy 7 was found in the bone marrow cells. At the age of 11 years he developed other characteristics of monosomy 7 including splenomegaly and anaemia. Some months later leukaemia was diagnosed.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research