Open AccessModulation of the spontaneous histamine release by adrenergic and cholinergic drugs
Author(s) -
Roberto Fantozzi,
Flavio Moroni,
Emanuela Masini,
Patrizio Blandina,
P. F. Mannaioni
Publication year - 1978
Publication title -
agents and actions
Language(s) - English
Resource type - Journals
eISSN - 2296-4509
pISSN - 0065-4299
DOI - 10.1007/bf01968614
Subject(s) - histamine , cholinergic , acetylcholine , chemistry , in vivo , histamine h3 receptor , adrenergic , in vitro , exocytosis , histamine h4 receptor , medicine , endocrinology , histamine h2 receptor , pharmacology , receptor , biology , secretion , biochemistry , antagonist , microbiology and biotechnology
Experiments have been reported on the possible modulation of the spontaneous histamine release by adrenergic and cholinergic drugs. Adrenergic drugs increase the spontaneous histamine release in vivo, and in neoplastic mast cells, in vitro. The mechanism of histamine release appears to be dependent upon the activation of alpha-adrenoceptors. Cholinergic drugs activate the release of histamine in many secretory processes in vivo; in vitro, acetylcholine is one of the most powerful histamine releasers in isolated purified rat mast cells. The release of histamine evoked by acetylcholine in rat mast cells is a calcium-requiring, temperature-dependent exocytosis. The physiological relationship of the sympathetic, parasympathetic and histamine-containing cells are discussed.