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Pregnancy in xanthinuria: Demonstration of fetal uric acid production?
Author(s) -
Simmonds H. A.,
Stutchbury J. H.,
Webster D. R.,
Spencer R. E.,
Fisher R. A.,
Wooder M.,
Buckley B. M.
Publication year - 1984
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf01805810
Subject(s) - uric acid , pregnancy , medicine , fetus , xanthine , urine , endocrinology , urinary system , obstetrics , biology , biochemistry , genetics , enzyme
This paper reports biochemical studies in a pregnant xanthinuric female (McKusick 27830) and compares the results with findings in three other xanthinurics studied by us, including a previously unreported female who had a nephrectomy for xanthine stones. The findings of raised levels of uric acid in plasma and urine at presentation in the third trimester of pregnancy, and the subsequent fall to almost undetectable levels 6 weeks post‐partum, is regarded as evidence of the extent of fetal uric acid production and clearance by the maternal circulation.