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β‐Mannosidase in human leukocytes and fibroblasts
Author(s) -
Panday R. S.,
Diggelen O. P.,
Kleijer W. J.,
Niermeijer M. F.
Publication year - 1984
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf01805598
Subject(s) - human genetics , immunology , fibroblast , biology , medicine , microbiology and biotechnology , cell culture , biochemistry , genetics , gene
In human leukocytes and fibroblasts β‐mannosidase activity has a unimodal pH optimum (4.0–4.5). Markedly reduced activity is found in I‐cell disease. Normal activities in human fibroblasts are ten times higher than in the goat, in which species a deficiency disease has been described.
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