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Fructose load test—an in vivo screening test designed to assess pyruvate dehydrogenase activity and interconversion
Author(s) -
Stansbie D.,
Sherriff R. J.,
Denton R. M.
Publication year - 1978
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf01805588
Subject(s) - in vivo , pyruvate dehydrogenase complex , fructose , lactate dehydrogenase , medicine , endocrinology , chemistry , biochemistry , enzyme , biology , genetics
An in vivo screening test is described, which is designed to assess the activity and interconversion of the human pyruvate dehydrogenase complex. Oral fructose was administered to six healthy subjects following (a) an overnight fast and (b) an oral glucose load. The rise in blood pyruvate and lactate levels following fructose was almost twice as great in the fasted state compared to the fed (post‐glucose) state. It is proposed that this difference is due to the conversion of pyruvate dehydrogenase to its active form, following feeding.