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The role of the blood‐brain barrier in the aetiology of permanent brain dysfunction in hyperphenylalaninaemia
Author(s) -
Hommes F. A.
Publication year - 1989
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf01805529
Subject(s) - blood–brain barrier , etiology , brain damage , medicine , endocrinology , central nervous system
Summary Calculations on the rate of entry of the neutral amino acids into the brain via the blood‐brain barrier show that a considerable decrease in this rate, particularly for tryptophan and tyrosine, takes place in histidinaemia and tyrosinaemia, type II. These conditions are, however, not associated with mental retardation. It is therefore concluded that effects at the blood‐brain barrier alone do not provide an adequate explanation for the aetiology of permanent brain dysfunction in hyperphenylalaninaemia.