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Relationship between plasma and red cell biopterins in acute and chronic hyperphenylalaninaemia
Author(s) -
Leeming R. J.,
Hall S. K.,
Surplice I. M.,
Green A.
Publication year - 1990
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf01800214
Subject(s) - biopterin , neopterin , tetrahydrobiopterin , medicine , endocrinology , hyperphenylalaninemia , red blood cell , red cell , blood plasma , chemistry , phenylalanine , biochemistry , nitric oxide synthase , amino acid , nitric oxide
Summary Biopterin concentrations in red blood cells were higher in patients with chronic hyperphenylalaninaemia than following a single oral dose of phenylalanine, although the plasma concentrations were similar. These findings suggest that tetrahydrobiopterin is synthesized in immature red blood cells in response to hyperphenylalaninaemia. The less marked increase in plasma biopterin suggests slow release from a tissue reservoir. The maintenance of a differential between erythrocyte and plasma biopterin concentrations suggests that some mechanism retains biopterin intracellularly.