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Allopurinol challenge test in children
Author(s) -
Burlina A. B.,
Ferrari V.,
DionisiVici C.,
Bordugo A.,
Zacchello F.,
Tuchman M.
Publication year - 1992
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf01800010
Subject(s) - orotic acid , allopurinol , medicine , creatinine , ingestion , urinary system , excretion , population , endocrinology , ornithine transcarbamylase deficiency , chemistry , biochemistry , urea cycle , environmental health , amino acid , arginine
Summary The allopurinol challenge test was performed on 44 healthy subjects (28 children and 16 adolescents) in order to establish normal values of urinary orotic acid excretion following allopurinol ingestion in the paediatric population. The subjects were divided into three groups according to their age: 6 months to 6 years; 6 years to 10 years; and 10 years to 17 years. They were given 100 mg, 200 mg, or 300 mg of allopurinol, respectively (based on age) in a single oral dose. Maximum peak urinary orotic acid levels following ingestion of allopurinol were 13.0 ( n =14), 9.3 ( n =14), and 10.2 ( n =16) µmol/mmol creatinine in the three groups, respectively. In all children tested the peak orotic acid level was 3.1±2.7 µmol/mmol creatinine (mean ± SD, n =44). This allopurinol challenge test was also performed in six children with ureacycle disorders, including five females with ornithine transcarbamylase (OTC) deficiency, all of whom demonstrated abnormally elevated levels of urinary orotic acid (peak levels of 26–134 µmol/mmol creatinine) following allopurinol ingestion.