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Normal hydroxylation of proline in collagen synthesized by skin fibroblasts from a patient with prolidase deficiency
Author(s) -
Royce P. M.,
Danks D. M.
Publication year - 1982
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf01800003
Subject(s) - hydroxylation , hydroxyproline , proline , medicine , chemistry , endocrinology , biochemistry , pathology , enzyme , amino acid
The extent of hydroxylation of proline in collagen synthesized and secreted into the culture medium by skin fibroblasts derived from a patient with prolidase deficiency has been examined and found to be normal. It would seem likely that to a considerable extent the urinary proline‐containing dipeptides apparent in this condition are derived from sources other than collagen.