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Azelaic and pimelic acids: Metabolic intermediates or artefacts?
Author(s) -
Bennett M. J.,
Ragni M. C.,
Hood I.,
Hale D. E.
Publication year - 1992
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf01799635
Subject(s) - azelaic acid , sebacic acid , adipic acid , urine , chemistry , biochemistry , organic chemistry
Summary Azelaic and pimelic acids are excreted in elevated amounts in urine in disorders of mitochondrial β‐oxidation and disorders of peroxisomal β‐oxidation, for which they are of significant diagnostic value. We have detected the presence of azelaic, pimelic and even‐chain‐length dicarboxylic acids (adipic, suberic and sebacic acids) arising artefactually as a result of storage of small sample volumes in plastic containers. Storage of samples for organic acid analysis in glass containers is recommended.