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The role of magnetic resonance spectroscopy in the investigation of lactic acidosis and inborn errors of energy metabolism
Author(s) -
Gadian D. G.,
Leonard J. V.
Publication year - 1996
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf01799115
Subject(s) - energy metabolism , metabolism , nuclear magnetic resonance spectroscopy , lactic acidosis , nuclear magnetic resonance , in vivo magnetic resonance spectroscopy , spectroscopy , in vivo , inborn error of metabolism , lactic acid , medicine , magnetic resonance imaging , chemistry , biology , bacteria , physics , radiology , genetics , quantum mechanics
Summary Magnetic resonance spectroscopy (MRS) provides a non‐invasive method of investigating disordered energy metabolism in vivo . Here, we briefly outline some MRS studies of skeletal muscle and brain metabolism that have been carried out in patients with inborn errors of energy metabolism. We concentrate in particular on the use of 1 H MRS for the detection of elevated brain lactate in these patients.