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Morphological studies of skeletal muscle in lactic acidosis
Author(s) -
Romero N. B.,
Lombès A.,
Touati G.,
Rigal O.,
Frachon P.,
Cheval M. A.,
Giraud M.,
Possekel S.,
Fardeau M.,
Ogier de Baulny H.
Publication year - 1996
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf01799113
Subject(s) - lactic acidosis , skeletal muscle , medicine , acidosis , human genetics , biology , endocrinology , biochemistry , gene
Summary This paper underscores the contribution of routine morphological examination of skeletal muscle in patients with lactic acidosis. Mitochondrial disorders are by far the most common causes of primary lactic acidosis, in which muscle biopsy analysis helps in diagnosis and in the search for the molecular anomalies. Thus, we focus our attention on one particular point: the contribution of the morphological study of muscle biopsy in primary lactic acidosis due to mitochondrial disorders, especially mitochondrial respiratory‐chain diseases.