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Regulation and function of the mitochondrial genome
Author(s) -
JeongYu S.,
Clayton D. A.
Publication year - 1996
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf01799105
Subject(s) - mitochondrial dna , biology , genetics , human mitochondrial genetics , dna replication , genome , dnaja3 , transcription (linguistics) , gene , dna , mitochondrion , mitochondrial biogenesis , human genome , human genetics , mitochondrial fusion , microbiology and biotechnology , linguistics , philosophy
Summary Molecular changes in human mitochondrial DNA play a significant role in causing certain human diseases. Mitochondrial DNA mutations range from single base pair changes in the 16.5 kilobase pair genome up to large deletions and rearrangements. This report summarizes the current overall understanding of the mode and mechanism of mitochondrial DNA replication and transcription, and how this relates to mitochondrial gene expression, which is essential for cellular energy production and organelle biogenesis. Special attention is given to recent findings that bear on early steps in the process of transcription and, in turn, the consequences for initiating DNA replication