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Hereditary variation of liver enzymes involved with detoxification and neurodegenerative disease
Author(s) -
Williams A. C.,
Steventon G. B.,
Sturman S.,
Waring R. H.
Publication year - 1991
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf01797916
Subject(s) - disease , pathogenesis , detoxification (alternative medicine) , monoamine oxidase , enzyme , parkinson's disease , endogeny , degenerative disease , medicine , metabolic pathway , biology , bioinformatics , biochemistry , immunology , pathology , alternative medicine
Summary Enzymes involved with the metabolic transformation of xenobiotics have recently been studied in patients with the neurodegenerative diseases, Alzheimer's disease, Parkinson's disease and motor neurone disease. Defects were detected in sulphur pathways and also, in the case of Parkinson's disease, in monoamine oxidase B. The possibility exists that the ability to cope safely with endogenous and exogenous substances which have neurotoxic properties is important in the pathogenesis of these diseases. Potentially such individuals could be identified preclinically and these diseases postponed by reduction in the load of toxin or modification of the relevant enzymic activity.