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Interleukin‐6 and granulocytic elastase levels following laparoscopic cholecystectomy
Author(s) -
Oka Masaaki,
Hazama Shoichi,
Hiwaki Kazuhisa,
Hiraki Sakurao,
Tangoku Akira,
Shimoda Kouji,
Suzuki Michinari,
Iizuka Norio,
Wadamori Kenji,
Suzuki Takashi
Publication year - 1994
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/bf01211922
Subject(s) - medicine , elastase , laparoscopic cholecystectomy , gastroenterology , cholecystectomy , neutrophil elastase , laparoscopic surgery , carcinoma , surgery , inflammation , laparoscopy , chemistry , enzyme , biochemistry
Abstract Interleukin‐6 (IL‐6) levels have been shown to correlate well with the magnitude of surgical stress. Serum IL‐6 and plasma granulocytic elastase levels, 24 h after surgery, were determined in 12 patients who underwent open major surgery [MS group; esophageal carcinoma ( n = 5), gastric carcinoma ( n = 3), colorectal carcinoma ( n = 4) 5 patients who had open cholecystectomy [OC group] and 17 patients who had laparoscopic cholecystectomy [LC group]. IL‐6 levels correlated significantly with the duration of surgery ( r = 0.685, P < 0.01) and with intraoperative blood loss ( r = 0.583, P < 0.02). However, there was no significant correlation between granulocytic elastase and the duration of surgery or blood loss. Plasma IL‐6 levels in the LC group (21±3 pg/ml) were significantly lower than those in the OC group (47 ± 5 pg/ml) and the MS group (186 ± 36pg/ml) ( P < 0.05; P < 0.01). However, there was no significant difference in granulocytic elastase levels between the LC group (318 ± 8μg/l), the OC group (360 ± 130 gmg/ml), and the MS group (701 ± 344 μg/l). Increased IL‐6 levels correlated well with increased duration of surgery. The lower IL‐6 levels following laparoscopic cholecystectomy may therefore be indicative of lower surgical stress associated with laparoscopic cholecystectomy.