An adaptive response to alkylating agents in Aspergillus nidulans | Zendy

Paul Hooley | Zendy; S.G. Shawcross | Zendy; Peter Strike | Zendy

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An adaptive response to alkylating agents in Aspergillus nidulans

Author(s) -

Paul Hooley,

S.G. Shawcross,

Peter Strike

Publication year - 1988

Publication title -

current genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.825

H-Index - 81

eISSN - 1432-0983

pISSN - 0172-8083

DOI - 10.1007/bf00521267

Subject(s) - aspergillus nidulans , biology , reversion , mutation , mycelium , strain (injury) , aspergillus , microbiology and biotechnology , genetics , biochemistry , mutant , gene , phenotype , botany , anatomy

A simple method is described for demonstrating adaptation to alkylation damage in Aspergillus nidulans. One wild type, two MNNG-sensitive, and one MNNG-resistant strain all showed improvement in colony growth when challenged with MNNG following appropriate inducing pretreatments. Other alkylating agents (MMS, EMS) could also adapt mycelium to later MNNG challenge, while 4NQO and UV could not. The inducible effect was not transmissible through conidia. A standard reversion assay based upon methG proved impractical for studying mutation frequencies during alkylation treatments owing to variations in MNNG resistance amongst revertants.

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