Metabolism of epidoxorubicin in animals: absence of glucuronidation | Zendy

Paul A. Maessen | Zendy; K. Mross | Zendy; Herbert M. Pinedo | Zendy; W. J. F. van der Vijgh | Zendy

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Metabolism of epidoxorubicin in animals: absence of glucuronidation

Author(s) -

Paul A. Maessen,

K. Mross,

Herbert M. Pinedo,

W. J. F. van der Vijgh

Publication year - 1987

Publication title -

cancer chemotherapy and pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.112

H-Index - 111

eISSN - 1432-0843

pISSN - 0344-5704

DOI - 10.1007/bf00252968

Subject(s) - glucuronidation , aglycone , cardiotoxicity , anthracycline , metabolism , pharmacology , chemistry , biochemistry , medicine , biology , toxicity , microsome , cancer , in vitro , glycoside , breast cancer , organic chemistry

Metabolism of epidoxorubicin was studied in plasma of seven different animal species at 2 h after administration of 4 mg/kg. None of the animals showed significant glucuronidation of epidoxorubicin, although small amounts of the glucuronides could be detected in the rabbit. However, large differences in formation of epidoxorubicinol and 7-deoxy (7d) doxorubicinol aglycone were observed between the species. These phenomena may be relevant for interspecies differences with regard to anthracycline-induced histomorphological changes in for example, heart tissues and cardiotoxicity in relation to formation of 7d aglycones.

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