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DIFFERENT H2 RECEPTOR ANTIHISTAMINES DISSIMILARLY RETARD THE GROWTH OF XENOGRAFTED HUMAN MELANOMA CELLS IN IMMUNODEFICIENT MICE
Author(s) -
Szincsák Nora,
Hegyesi Hargita,
Hunyadi Janos,
Falus Andras,
Juhász Istvan
Publication year - 2002
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.2002.0934
Subject(s) - cimetidine , histamine , histamine h2 receptor , autocrine signalling , receptor , histamine h4 receptor , pharmacology , chemistry , in vivo , antagonist , paracrine signalling , receptor antagonist , histamine receptor , in vitro , ranitidine , cancer research , biology , biochemistry , microbiology and biotechnology
Melanoma cells and tissues contain considerable amounts of histamine and express histamine receptors, suggesting the existence of autocrine and paracrine regulation by histamine. Our previous in vitro results suggested that histamine elevates melanoma cell growth through the H2 receptor. In this work we show that in vivo tumour proliferation in immunodeficient mice xenotransplanted with a human melanoma cell line is diminished by cimetidine, an H2 receptor antagonist, if combined with a tamoxifen derivate acting on cytochrome p450 molecules (DPPE). Ranitidine, another H2 receptor antagonist, has a weaker inhibitory effect, the kinetics and mechanism of which is probably dissimilar to that of the cimetidine/DPPE mixture.