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INSULIN‐MEDIATED TYROSINE PHOSPHORYLATION OF MYOSIN HEAVY CHAIN AND CONCOMITANT ENHANCED ASSOCIATION OF C‐TERMINAL SRC KINASE DURING SKELETAL MUSCLE DIFFERENTIATION
Author(s) -
Goel Hira Lal,
Dey Chinmoy Sankar
Publication year - 2002
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.2002.0878
Subject(s) - myosin , myosin light chain kinase , phosphorylation , proto oncogene tyrosine protein kinase src , skeletal muscle , insulin receptor , insulin , tyrosine phosphorylation , tyrosine kinase , microbiology and biotechnology , chemistry , tyrosine , biology , biochemistry , endocrinology , signal transduction , insulin resistance
In this study, we present for the first time: (1) evidence regarding tyrosine phosphorylation of myosin heavy chain, (2) evidence that insulin can phosphorylate myosin, (3) association of myosin with Csk, a signalling molecule, (4) modulation of this association by insulin, and (5) evidence that these interactions are associated with skeletal muscle differentiation.