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OVER‐EXPRESSION OF K‐FGF OR bFGF RESULTS IN ALTERED EXPRESSION OF MATRIX METALLOPROTEINASES: CORRELATIONS WITH MALIGNANT PROGRESSION AND CELLULAR INVASION
Author(s) -
Lo James,
Hurta Robert A. R.
Publication year - 2002
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.2001.0858
Subject(s) - matrix metalloproteinase , proteases , fibroblast growth factor , malignant transformation , basic fibroblast growth factor , biology , microbiology and biotechnology , transformation (genetics) , cancer research , growth factor , receptor , enzyme , gene , biochemistry
Matrix metalloproteinase (MMP) expression was investigated in NIH‐3T3 fibroblasts that secrete K‐FGF and in NIH‐3T3 cells which express chimeric bFGF with a signal sequence targeting bFGF to the secretory pathway. Correlations between altered MMPs' and other proteases' expression and malignant potential were determined. Correlations between the expression of MMPs and the invasion ability of K‐FGF and bFGF over‐expressing cells were also determined. The resulting correlation between alterations in proteases and malignant progression supports a model which suggests that growth factor modulation of protease expression is part of the altered growth regulatory program associated with cellular transformation and malignant progression.