Premium
HUMAN ARTICULAR CHONDROCYTES EXPRESS THREE FACILITATIVE GLUCOSE TRANSPORTER ISOFORMS: GLUT1, GLUT3 AND GLUT9
Author(s) -
Mobasheri A.,
Neama G.,
Bell S.,
Richardson S.,
Carter S. D.
Publication year - 2002
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.2001.0850
Subject(s) - glut3 , glut1 , glucose transporter , chondrocyte , gene isoform , cartilage , microbiology and biotechnology , chemistry , glut4 , articular cartilage , transporter , endocrinology , medicine , biology , biochemistry , anatomy , pathology , osteoarthritis , gene , insulin , alternative medicine
Glucose is an important metabolite and a structural precursor for articular cartilage and its transport has significant consequences for cartilage development and functional integrity. In this study the expression of facilitative glucose transporters (GLUTs) in human chondrocytes was investigated. Results showed that at least three GLUT isoforms (GLUT1, GLUT3 and GLUT9) are expressed by normal chondrocytes. Given the central role of glucose in chondrocyte physiology and metabolism, its regular provision via GLUTs will influence the metabolic activity and survival of chondrocytes in cartilage matrices.