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CISPLATIN INDUCES MODIFICATIONS IN THE DEVELOPMENT OF CELL SURFACE PATTERNS OF CILIATES
Author(s) -
Machwe Swati,
Arora Seema,
Gupta Renu,
Sapra G. R.
Publication year - 2001
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.2001.0796
Subject(s) - cilium , organelle , primordium , microbiology and biotechnology , cisplatin , ciliate , tetrahymena , cdc42 , biology , cell , chemistry , biochemistry , actin , genetics , chemotherapy , gene
Cisplatin [ cis ‐dichlorodiammineplatinum (II)] brings about significant quantitative modifications in the development of cell surface patterns in two unrelated ciliates: Stylonychia and Tetrahymena . Cells cultured in the presence of cisplatin exhibit the formation of supernumerary surface structures in the form of extra cilia/cirri (fused cilia) and other organized ciliary organelles. The metal‐induced formation of extra primordia and their differentiation into supernumerary ciliary structures is governed by the normal rules of development. Additional structures are accommodated within the framework of a defined pattern, suggesting the existence of an overall global control of pattern formation. The modified pattern is rectified to its normal state during post‐treatment fission cycles, suggesting the role of the cell membrane in correcting developmental errors.