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EFFECT OF NEONATAL INTERLEUKIN‐6 (IL‐6) TREATMENT (HORMONAL IMPRINTING) ON THE IL‐6 CONTENT AND LOCALIZATION OF THE PERITONEAL, BLOOD AND THYMIC CELLS OF ADULT RATS. A CONFOCAL MICROSCOPIC ANALYSIS
Author(s) -
Csaba György,
Kovács Péter
Publication year - 2001
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.2001.0782
Subject(s) - lymphatic system , biology , mast cell , imprinting (psychology) , confocal microscopy , immunology , pathology , microbiology and biotechnology , endocrinology , medicine , biochemistry , gene
Single treatment of newborn rat with human recombinant interleukin‐6 (IL‐6) durably increases IL‐6 content in certain cell types of the adult animal. Peritoneal mast cells contain a high quantity of IL‐6, in contrast to controls which contain no IL‐6. In addition, many other (mainly lymphatic) cells of the peritoneal fluid contain IL‐6. However, IL‐6 is present in the control thymocytes, in smaller amounts than in the neonatally IL‐6 imprinted cells. In the blood, the number of IL‐6 containing cells also increases after imprinting (lymphocytes and developing forms of mast cells).