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EFFECTS OF INSULIN‐LIKE GROWTH FACTOR‐BINDING PROTEIN 2 AND AN IGF‐TYPE I RECEPTOR‐BLOCKING ANTIBODY ON APOPTOSIS IN HUMAN TERATOCARCINOMA CELLS IN VITRO
Author(s) -
Granerus Marika,
Engström Wilhelm
Publication year - 2001
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.2001.0756
Subject(s) - teratocarcinoma , apoptosis , receptor , in vitro , antibody , blocking (statistics) , microbiology and biotechnology , programmed cell death , growth factor , cell culture , biology , chemistry , cancer research , cellular differentiation , biochemistry , immunology , statistics , genetics , mathematics , gene
Human teratocarcinoma cells (Tera‐2) deprived of serum undergo programmed cell death which can be counteracted by simultaneous addition of IGF‐I or IGF‐II. This protective effect of IGFs was specific in the sense that both addition of IGF‐binding protein‐2, and blocking of the IGF‐type I receptor by a specific antibody, both resulted in an increased apoptotic rate.