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APOPTOTIC AND MITOTIC ACTIVITY IN SQUAMOUS CELL CARCINOMA CELLS AFTER COMBINED MODALITY TREATMENT WITH γ‐IRRADIATION AND DIBROMODULCITOL
Author(s) -
Kraxner H.,
Tamás L.,
Sáfrány G.,
Ribári O.,
Oláh I.,
Hidvégi E.,
Répássy G.,
Szende B.
Publication year - 2001
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.2000.0707
Subject(s) - apoptosis , irradiation , cancer research , mitosis , basal cell , in vitro , cell , radiation therapy , cell growth , chemistry , biology , pathology , medicine , microbiology and biotechnology , biochemistry , physics , nuclear physics
A‐431 squamous cell carcinoma cells were treated in vitro with either 4Gy radiatio of 15 (or 45) μg/ml dibromodulcitol (DBD), as well as with combined 4Gy irradiation and DBD, with the latter as either a pretreatment or post‐treatment. DBD alone or in combination with radiation had a greater effect on cell proliferation than the effect of radiation alone. The difference is due to a higher level of apoptosis induced by DBD, especially in conjunction with radiation. Such a combination may therefore be useful in the treatment of squamous cell carcinoma, which in general responds poorly to radiation therapy.