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PDGF‐BB AND IGF‐I USE DIFFERENT SIGNALING PATHWAYS TO INDUCE FIBRONECTIN SYNTHESIS IN CULTURED RAT THORACIC AORTIC SMOOTH MUSCLE CELLS
Author(s) -
Lo Chu S.
Publication year - 2001
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.2000.0622
Subject(s) - fibronectin , platelet derived growth factor receptor , growth factor , microbiology and biotechnology , extracellular matrix , platelet derived growth factor , signal transduction , chemistry , biology , biochemistry , receptor
Fibronectin, an extracellular matrix protein, acts as an early signal in initiating cell proliferation. Results have indicated that platelet‐derived growth factor BB (PDGF‐BB) and insulin‐like growth factor‐I (IGF‐I) both enhance fibronectin gene expression. Genistein inhibits PDGF‐BB‐induced fibronectin levels without inhibiting IGF‐I‐induced fibronectin levels. It indicates that PDGF‐BB and IGF‐I utilize separate signaling pathways to induce the synthesis of fibronectin.