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INVOLVEMENT OF PI 3‐KINASE, PKA AND PKC IN PDGF‐ AND TGF‐β‐MEDIATED PREVENTION OF 2‐DEOXY‐D‐RIBOSE‐INDUCED APOPTOSIS IN THE INSECT CELL LINE, IPLB‐LdFB
Author(s) -
Ottaviani Enzo,
Barbieri Daniela,
Malagoli Davide,
Kletsas Dimitris
Publication year - 2001
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.2000.0582
Subject(s) - protein kinase c , apoptosis , kinase , microbiology and biotechnology , oxidative stress , programmed cell death , chemistry , protein kinase a , biochemistry , biology
Activation of phosphatidylinositol (PI) 3‐kinase, protein kinase A (PKA) and protein kinase C (PKC) is associated with the survival effect elicited by PDGF‐AB and TGF‐β1 against the apoptotic inducer 2‐deoxy‐D‐ribose (dRib) in the fat body cell line, IPLB‐LdFB, from the insect Lymantria dispar . dRib induces apoptosis and provokes mitochondrial membrane depolarization (MMD). The antioxidant N ‐acetyl‐L‐cysteine annuls only the first effect. These findings suggest that apoptosis and MMD are provoked by two different mechanisms, and that dRib induces apoptosis by oxidative stress.