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CYTOTOXICITY BY STORED HUMAN BREAST‐MILK: POSSIBLE CONTRIBUTION OF COMPLEMENT SYSTEM
Author(s) -
Ogundele Michael Oladipo
Publication year - 1999
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1999.0425
Subject(s) - cytolysis , calcium , cytotoxicity , in vitro , chemistry , cytotoxic t cell , complement system , complement (music) , magnesium , biochemistry , food science , biology , immunology , immune system , organic chemistry , complementation , gene , phenotype
Human milk stored over some period in vitro possesses certain cytotoxic properties, which require further studies. Cytolysis induced by stored human milk has now been further characterized, using rabbit red blood cells as targets, to determine the contribution of other components, particularly the complement system. Cytolysis was found to be temperature dependent, greatly enhanced by low concentrations of magnesium and calcium ions, but inhibited by moderate to excessive amounts of calcium ions, and by heating at 56°C.