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EFFECT OF THE IMPase INHIBITOR L690,330 ON SEA URCHIN DEVELOPMENT
Author(s) -
SCONZO GABIELLA,
CASCINO DOMENICO,
AMORE GABRIELE,
GERACI FABIANA,
GIUDICE GIOVANNI
Publication year - 1998
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1998.0229
Subject(s) - sea urchin , chemistry , zoology , biology , fishery , microbiology and biotechnology
A variety of concentrations of the IMPase inhibitor L690,330 were added to sea urchin embryos. Immediate arrest of development was obtained for concentrations from 7.5m m on. Concentrations lower than 3.5m m permitted gastrulation but inhibited skeletogenesis and disturbed elongation along the animal—vegetal axis. The latter results are similar to those obtained by counteracting lithium effect with myoinositol, which are suggested to be due to partial relief of IMPase inhibition.