Premium
DECREASED DENSITIES OF INTRAMEMBRANOUS PARTICLES AND CYTOCHEMICALLY DETECTABLE CHOLESTEROL IN MICROVILLI OF STARVED RAT ENTEROCYTES
Author(s) -
WAHEED A. A.,
TOYAMA Y.,
YASUZUMI F.,
GUPTA P. D.
Publication year - 1998
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1998.0227
Subject(s) - filipin , intramembranous ossification , sterol , cholesterol , brush border , microbiology and biotechnology , biology , membrane fluidity , membrane , chemistry , biochemistry , biophysics , vesicle
The densities of intramembranous particles (IMPs) and of sterol complexes induced by treatment of filipin were studied by freeze‐fracture replication of intact intestine and/or isolated brush border membranes (BBM) of well‐fed and starved rats. The density of IMPs and filipin‐sterol complexes (FSCs) decrease considerably during starvation. Biochemical estimations show a decrease in the levels of cholesterol and proteins with respect to phospholipids during starvation which is in agreement with morphological findings. It is suggested that these changes may play a role in regulating membrane fluidity which in turn affects absorption of nutrients through BBM.