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ALPHA‐FETOPROTEIN‐MEDIATED TARGETING—A NEW STRATEGY TO OVERCOME MULTIDRUG RESISTANCE OF TUMOUR CELLS IN VITRO
Author(s) -
MOSKALEVA ELIZAVETA YU.,
POSYPANOVA GALINA A.,
SHMYREV IGOR I.,
RODINA ALLA V.,
MUIZHNEK EKATERINA L.,
SEVERIN EUGENE S.,
KATUKOV VALERY YU.,
LUZHKOV YURY M.,
SEVERIN SERGEI E.
Publication year - 1997
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1998.0201
Subject(s) - in vitro , multiple drug resistance , cancer research , chemistry , biology , drug resistance , microbiology and biotechnology , biochemistry
Abstract The possibility of overcoming the multidrug resistance of human malignant cells by using doxorubicin conjugated to alpha‐fetoprotein (AFP) was studied. It was shown that this type of antitumour drugs, penetrating the cell by receptor‐mediated endocytosis with AFP as a vehicle, raises the sensitivity of the tumour cells that are resistant due to the expression of the multidrug resistance gene mdr 1. The sensitivity of antibiotic‐resistant cell lines SKVLB (a human ovarian carcinoma) and MCF‐7 AdrR (a human breast carcinoma) increased by 10‐ and 4‐fold, respectively, when AFP‐conjugated doxorubicin was used. The rationale of using human AFP‐antitumour drug conjugates for the development of new chemotherapeutic approaches to cancer treatment is discussed.