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EFFECTS OF DIPEPTIDES CONTAINING THE AMINO ACID, PROLINE ON THE CHEMOTAXIS OF TETRAHYMENA PYRIFORMIS . EVOLUTIONARY CONCLUSIONS ON THE FORMATION OF HORMONE RECEPTORS AND HORMONES
Author(s) -
KÖHIDAI LÁSZLÓ,
SOÓS PÁL,
CSABA GYÖRGY
Publication year - 1997
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1997.0161
Subject(s) - tetrahymena pyriformis , amino acid , proline , dipeptide , tetrahymena , side chain , biochemistry , valine , chemotaxis , lipophilicity , stereochemistry , biology , chemistry , receptor , organic chemistry , polymer
Our investigations demonstrate that proline‐containing dipeptides can provoke a chemosensory response from the unicellular Tetrahymena pyriformis The chemotactic effects of the dipeptides have a close relationship with the side chain and the lipophilicity of the amino‐terminal amino acid. Comparison of ‘mirror’ variants of proline‐containing dipeptides points to the fact that dipeptides with small side chain and non‐polar character amino acids (Gly‐Pro, Ala‐Pro) are preferred on the amino‐terminal end. In the case of amino acids with very variable side chains, small (Pro‐Gly) and the large side chain and non‐polar character amino acids (Pro‐Leu, Pro‐Phe) on the carboxyl‐terminal end can induce significant chemotactic responses. With valine on any terminus the proline‐containing dipeptide induced a weak repellent effect.