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COMPARISON OF THE EFFECT OF DIFFERENT SHORT CHAIN FATTY ACIDS ON THE GROWTH AND DIFFERENTIATION OF HUMAN COLONIC CARCINOMA CELL LINES IN VITRO
Author(s) -
SIAVOSHIAN SAMILA,
BLOTTIÈRE HERVÉ M,
FOLL ERIC,
KAEFFER BERTRAND,
CHERBUT CHRISTINE,
GALMICHE JEANPAUL
Publication year - 1997
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1997.0153
Subject(s) - valerate , butyrate , propionate , cell growth , cell culture , alkaline phosphatase , chemistry , estradiol valerate , cell , biochemistry , biology , enzyme , fermentation , hormone , genetics
Abstract The aim of this study was to compare the effects of acetate, propionate, butyrate, iso‐butyrate, valerate, iso‐valerate and caproate on cell growth and on the activities of alkaline phosphatase (AP) and dipeptidyl aminopeptidase IV (DPP IV) by three human colonic adenocarcinoma cell lines. In addition to butyrate, propionate and valerate inhibited cell proliferation of the three cell lines. The other SCFAs did not influence cell proliferation. AP and DPP IV activities were strongly stimulated by butyrate on two of the three cell lines. On HT‐29, AP was strongly stimulated, however DPPIV expression remained undetectable. Propionate and valerate exhibited a weaker stimulation, the other SCFAs being ineffective. The effect of SCFAs on cell proliferation and differentiation clearly depends on the number of carbons and on the configuration of the basic structure of the molecule.