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ANTIPROLIFERATIVE EFFECT OF ILLIMAQUINONE ON LEISHMANIA MEXICANA
Author(s) -
RANGEL HECTOR R.,
DAGGER FRACEHULI,
COMPAG REINALDO S.
Publication year - 1997
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1997.0143
Subject(s) - golgi apparatus , leishmania mexicana , microbiology and biotechnology , ultrastructure , intracellular , biology , leishmania , function (biology) , metabolite , acid phosphatase , chemistry , biochemistry , cell , enzyme , parasite hosting , anatomy , world wide web , computer science
Illimaquinone, a sponge metabolite that disrupts the Golgi complex in mammalian cells, stopped proliferation and induced morphological and ultrastructural changes in promastigotes of L. mexicana Radioactive labeling of proteins demonstrates an increased excretion function and diminution of membrane acid phosphatase activity, due probably to the vesiculation of the Golgi complex and alteration of the cell protein sorting mechanism. The result indicated that illimaquinone could be useful for the study of intracellular traffic in Trypanosomatidae.